Can arginine and ornithine support gut functions? (2024)

. 1994 Jan;35(1 Suppl):S42–S45. doi: 10.1136/gut.35.1_suppl.s42

L Cynober

1

PMCID: PMC1378146PMID: 8125389

Abstract

Arginine and ornithine are precursors of nitric oxide and polyamines, respectively. These metabolites intimately participate in permeability and adaptive responses of the gut. The liver possesses high arginase activity as an intrinsic part of urea synthesis and would consume most of the portal supply of dietary arginine. The gut reduces this possibility by converting dietary arginine to citrulline, which effectively bypass the liver and is resynthesized to arginine in the kidney. Dietary ornithine supplementation, in the form of ornithine alpha-ketoglutarate (OKG) can be considered as an arginine precursor. Several supplement studies have shown both amino acids to promote growth hormone and insulin secretion with anabolic effects in postoperative patients. Their intermediary metabolites (for example, glutamine, proline) may also be of benefit in trauma metabolism. Specific effects of either amino acid on the gut are poorly reported. One recent animal study showed improved morphology after OKG administration, perhaps through increased polyamine secretion. Generation of nitric oxide from arginine has two facets. Excess production from high dose arginine potentiated the effects of experimentally induced sepsis, whereas low doses improved survival. These considerations suggest that the role of enteral diet supplementation with arginine or OKG should be urgently examined for any benefits it may have on mucosal barrier function.

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Can arginine and ornithine support gut functions? (1)

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alarcon P., Lin C. H., Lebenthal E., Lee P. C. Interaction of malnutrition and difluoromethylornithine-induced intestinal mucosal damage: degree of severity and subsequent recovery. Digestion. 1988;41(2):68–77. doi: 10.1159/000199734. [DOI] [PubMed] [Google Scholar]
  2. Barbul A. Arginine and immune function. Nutrition. 1990 Jan-Feb;6(1):53–62. [PubMed] [Google Scholar]
  3. Barbul A. Arginine: biochemistry, physiology, and therapeutic implications. JPEN J Parenter Enteral Nutr. 1986 Mar-Apr;10(2):227–238. doi: 10.1177/0148607186010002227. [DOI] [PubMed] [Google Scholar]
  4. Barbul A., Lazarou S. A., Efron D. T., Wasserkrug H. L., Efron G. Arginine enhances wound healing and lymphocyte immune responses in humans. Surgery. 1990 Aug;108(2):331–337. [PubMed] [Google Scholar]
  5. Blachier F., Darcy-Vrillon B., Sener A., Duée P. H., Malaisse W. J. Arginine metabolism in rat enterocytes. Biochim Biophys Acta. 1991 May 17;1092(3):304–310. doi: 10.1016/s0167-4889(97)90005-7. [DOI] [PubMed] [Google Scholar]
  6. Blachier F., M'Rabet-Touil H., Darcy-Vrillon B., Posho L., Duee P. H. Stimulation by D-glucose of the direct conversion of arginine to citrulline in enterocytes isolated from pig jejunum. Biochem Biophys Res Commun. 1991 Jun 28;177(3):1171–1177. doi: 10.1016/0006-291x(91)90663-r. [DOI] [PubMed] [Google Scholar]
  7. Cynober L., Coudray-Lucas C., de Bandt J. P., Guéchot J., Aussel C., Salvucci M., Giboudeau J. Action of ornithine alpha-ketoglutarate, ornithine hydrochloride, and calcium alpha-ketoglutarate on plasma amino acid and hormonal patterns in healthy subjects. J Am Coll Nutr. 1990 Feb;9(1):2–12. doi: 10.1080/07315724.1990.10720343. [DOI] [PubMed] [Google Scholar]
  8. Cynober L. Ornithine alpha-ketoglutarate in nutritional support. Nutrition. 1991 Sep-Oct;7(5):313–322. [PubMed] [Google Scholar]
  9. D'Agostino L., Daniele B., Pignata S., Barone M. V., D'Argenio G., Mazzacca G. Modifications in ornithine decarboxylase and diamine oxidase in small bowel mucosa of starved and refed rats. Gut. 1987;28 (Suppl):135–138. doi: 10.1136/gut.28.suppl.135. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Gonce S. J., Peck M. D., Alexander J. W., Miskell P. W. Arginine supplementation and its effect on established peritonitis in guinea pigs. JPEN J Parenter Enteral Nutr. 1990 May-Jun;14(3):237–244. doi: 10.1177/0148607190014003237. [DOI] [PubMed] [Google Scholar]
  11. Grillo M. A. Metabolism and function of polyamines. Int J Biochem. 1985;17(9):943–948. doi: 10.1016/0020-711x(85)90238-1. [DOI] [PubMed] [Google Scholar]
  12. Herzfeld A., Raper S. M. The heterogeneity of arginases in rat tissues. Biochem J. 1976 Feb 1;153(2):469–478. doi: 10.1042/bj1530469. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Hosomi M., Smith S. M., Murphy G. M., Dowling R. H. Polyamine distribution in the rat intestinal mucosa. J Chromatogr. 1986 Mar 7;375(2):267–275. doi: 10.1016/s0378-4347(00)83719-6. [DOI] [PubMed] [Google Scholar]
  14. Jain R., Eikenburg B. E., Johnson L. R. Stimulation of ornithine decarboxylase activity in digestive tract mucosa. Am J Physiol. 1987 Sep;253(3 Pt 1):G303–G307. doi: 10.1152/ajpgi.1987.253.3.G303. [DOI] [PubMed] [Google Scholar]
  15. Johnson L. R., Tseng C. C., Wang P., Tipnis U. R., Haddox M. K. Mucosal ornithine decarboxylase in the small intestine: localization and stimulation. Am J Physiol. 1989 Mar;256(3 Pt 1):G624–G630. doi: 10.1152/ajpgi.1989.256.3.G624. [DOI] [PubMed] [Google Scholar]
  16. Jones M. E. Conversion of glutamate to ornithine and proline: pyrroline-5-carboxylate, a possible modulator of arginine requirements. J Nutr. 1985 Apr;115(4):509–515. doi: 10.1093/jn/115.4.509. [DOI] [PubMed] [Google Scholar]
  17. Kilbourn R. G., Gross S. S., Jubran A., Adams J., Griffith O. W., Levi R., Lodato R. F. NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide. Proc Natl Acad Sci U S A. 1990 May;87(9):3629–3632. doi: 10.1073/pnas.87.9.3629. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Kumagai J., Jain R., Johnson L. R. Characteristics of spermidine uptake by isolated rat enterocytes. Am J Physiol. 1989 May;256(5 Pt 1):G905–G910. doi: 10.1152/ajpgi.1989.256.5.G905. [DOI] [PubMed] [Google Scholar]
  19. León P., Redmond H. P., Stein T. P., Shou J., Schluter M. D., Kelly C., Lanza-Jacoby S., Daly J. M. Harry M. Vars Research Award. Arginine supplementation improves histone and acute-phase protein synthesis during gram-negative sepsis in the rat. JPEN J Parenter Enteral Nutr. 1991 Sep-Oct;15(5):503–508. doi: 10.1177/0148607191015005503. [DOI] [PubMed] [Google Scholar]
  20. Luk G. D., Yang P. Polyamines in intestinal and pancreatic adaptation. Gut. 1987;28 (Suppl):95–101. doi: 10.1136/gut.28.suppl.95. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Marletta M. A. Nitric oxide: biosynthesis and biological significance. Trends Biochem Sci. 1989 Dec;14(12):488–492. doi: 10.1016/0968-0004(89)90181-3. [DOI] [PubMed] [Google Scholar]
  22. McCormack S. A., Johnson L. R. Role of polyamines in gastrointestinal mucosal growth. Am J Physiol. 1991 Jun;260(6 Pt 1):G795–G806. doi: 10.1152/ajpgi.1991.260.6.G795. [DOI] [PubMed] [Google Scholar]
  23. Meijer A. J., Lamers W. H., Chamuleau R. A. Nitrogen metabolism and ornithine cycle function. Physiol Rev. 1990 Jul;70(3):701–748. doi: 10.1152/physrev.1990.70.3.701. [DOI] [PubMed] [Google Scholar]
  24. Merimee T. J., Lillicrap D. A., Rabinowitz D. Effect of arginine on serum-levels of human growth-hormone. Lancet. 1965 Oct 2;2(7414):668–670. doi: 10.1016/s0140-6736(65)90399-5. [DOI] [PubMed] [Google Scholar]
  25. Minami H., Miyamoto K., Fujii Y., Nakabou Y., Hagihira H. Induction of intestinal ornithine decarboxylase by single amino acid feeding. J Biochem. 1985 Jul;98(1):133–139. doi: 10.1093/oxfordjournals.jbchem.a135251. [DOI] [PubMed] [Google Scholar]
  26. Moncada S., Palmer R. M., Higgs E. A. Biosynthesis of nitric oxide from L-arginine. A pathway for the regulation of cell function and communication. Biochem Pharmacol. 1989 Jun 1;38(11):1709–1715. doi: 10.1016/0006-2952(89)90403-6. [DOI] [PubMed] [Google Scholar]
  27. Morimoto B. H., Brady J. F., Atkinson D. E. Effect of level of dietary protein on arginine-stimulated citrulline synthesis. Correlation with mitochondrial N-acetylglutamate concentrations. Biochem J. 1990 Dec 15;272(3):671–675. doi: 10.1042/bj2720671. [DOI] [PMC free article] [PubMed] [Google Scholar]
  28. Oratz M., Rothschild M. A., Schreiber S. S., Burks A., Mongelli J., Matarese B. The role of the urea cycle and polyamines in albumin synthesis. Hepatology. 1983 Jul-Aug;3(4):567–571. doi: 10.1002/hep.1840030415. [DOI] [PubMed] [Google Scholar]
  29. Pegg A. E. Recent advances in the biochemistry of polyamines in eukaryotes. Biochem J. 1986 Mar 1;234(2):249–262. doi: 10.1042/bj2340249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Rennie M. J., Hundal H. S., Babij P., MacLennan P., Taylor P. M., Watt P. W., Jepson M. M., Millward D. J. Characteristics of a glutamine carrier in skeletal muscle have important consequences for nitrogen loss in injury, infection, and chronic disease. Lancet. 1986 Nov 1;2(8514):1008–1012. doi: 10.1016/s0140-6736(86)92617-6. [DOI] [PubMed] [Google Scholar]
  31. Seifter E., Rettura G., Barbul A., Levenson S. M. Arginine: an essential amino acid for injured rats. Surgery. 1978 Aug;84(2):224–230. [PubMed] [Google Scholar]
  32. Seiler N., Daune G., Bolkenius F. N., Knödgen B. Ornithine aminotransferase activity, tissue ornithine concentrations and polyamine metabolism. Int J Biochem. 1989;21(4):425–432. doi: 10.1016/0020-711x(89)90367-4. [DOI] [PubMed] [Google Scholar]
  33. Tuchman M., Holzknecht R. A. N-acetylglutamate content in liver and gut of normal and fasted mice, normal human livers, and livers of individuals with carbamyl phosphate synthetase or ornithine transcarbamylase deficiency. Pediatr Res. 1990 Apr;27(4 Pt 1):408–412. doi: 10.1203/00006450-199004000-00020. [DOI] [PubMed] [Google Scholar]
  34. Vaubourdolle M., Coudray-Lucas C., Jardel A., Ziegler F., Ekindjian O. G., Cynober L. Action of enterally administered ornithine alpha-ketoglutarate on protein breakdown in skeletal muscle and liver of the burned rat. JPEN J Parenter Enteral Nutr. 1991 Sep-Oct;15(5):517–520. doi: 10.1177/0148607191015005517. [DOI] [PubMed] [Google Scholar]
  35. Vaubourdolle M., Jardel A., Coudray-Lucas C., Ekindjian O. G., Agneray J., Cynober L. Fate of enterally administered ornithine in healthy animals: interactions with alpha-ketoglutarate. Nutrition. 1989 May-Jun;5(3):183–187. [PubMed] [Google Scholar]
  36. Vaubourdolle M., Salvucci M., Coudray-Lucas C., Agneray J., Cynober L., Ekindjian O. G. Action of ornithine alpha ketoglutarate on DNA synthesis by human fibroblasts. In Vitro Cell Dev Biol. 1990 Feb;26(2):187–192. doi: 10.1007/BF02624111. [DOI] [PubMed] [Google Scholar]
  37. Wernerman J., Hammarkvist F., Ali M. R., Vinnars E. Glutamine and ornithine-alpha-ketoglutarate but not branched-chain amino acids reduce the loss of muscle glutamine after surgical trauma. Metabolism. 1989 Aug;38(8 Suppl 1):63–66. doi: 10.1016/0026-0495(89)90144-3. [DOI] [PubMed] [Google Scholar]
Can arginine and ornithine support gut functions? (2024)
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